Wednesday, 11 March 2015

The story of steroid Dianabol in athletics

In 1954, a physician named John Ziegler attended the World Weightlifting Championships in Vienna, Austria, as the team's doctor. The Soviets dominated the competition that year, easily breaking several world records and winning gold medals in legions of weight classes. According to anecdotal reports, Ziegler invited the Soviet´s team doctor to a bar and the doctor told him that that his lifters had used testosterone injections as part of their training programs. Whether that story is true or not, ultimately, the Americans returned from the World Championships that year and immediately began their efforts to defeat the Soviets using pharmaceutical enhancement.

As you may have expected, when they returned to the United States, the team doctor began administering straight testosterone to his weightlifters. He also got involved with Ciba, the large pharmaceutical firm, and attempted to synthesize a substance with strength enhancing effects comparable or better than testosterone's. In 1956, Methandrostenolone was created, and given the name "Dianabol".

In the following years, little pink Dianabol tablets found their way into many weightlifter´s training program, fast forward a few years, and in the early 1960s, there was a clear gap between Ziegler´s weightlifters and the rest of the country, and much less of one between them and the Soviets. It was also in the 1960´s that another anabolic steroid had been developed and used to treat short stature in children with Turner Disease syndrome.

At this time, physicians around the United States began to take notice of steroids, and numerous studies were performed on athletes taking them, in an effort to stem the tide of athletes attempting to obtain steroids for use in sports.
The early studies on steroids clearly showed that anabolic steroids offered no athletic benefit whatsoever, but in retrospect can be said to have several design flaws. The first issue with those studies, and the most glaring one was that the doses were usually very low, too low to really produce much of an effect at all. In addition, it was neither common for these studies to not be double blind nor to be randomized. A double blind study is one where neither the scientists nor the subjects of the study know if they are getting a real medication or a placebo. A randomized study is where the real medicine is randomly dispersed throughout the test group. Finally, in those early studies, nutrition and exercise was not really controlled or standardized. Not long after those flawed studies were concluded, the Physicians Desk Reference boldly (and wrongly) claimed that anabolic steroids were not useful in enhancing athletic performance. Despite this, in 1967, the International Olympic Council banned the use of anabolic steroids and by the mid 1970´s most major sporting organizations had also banned them.

Steroids in Olympics:

Just prior to the ban on steroids in the Olympics, the German Democratic Republic (GDR) began a program with the goals of synthesizing new anabolic steroids for their athletes to use in various sports. Their body of research remains the most extensive collection of information on the use of steroids in athletes ever complied. Despite the small size of their country, they managed to consistently dominate the top ranks of various sports.

By 1982, the International Olympic Council had developed a test for the detection of excess levels of testosterone in athletes, known as the "Testosterone: Epitestosterone test". In this test, levels of testosterone vs/ epitestosterone are measured, and if the testosterone level is 6x that of the epitestosterone level, it can safely be concluded that some form of testosterone has been used by the athlete. This is because testosterone is commonly no more than 6x the natural level of epitestosterone found naturally in the body. Thus, if there were more than that ratio, it was not naturally occurring, in all probability. The IOC was, as usual, one step behind the athletes. The GDR had already done a study on their athletes using a form of testosterone which would leave the body quickly, and thus they would be ready for the IOC test within three days of their last injection. They then developed a protocol to allow their athletes to continue steroid use, ceasing it only long enough to pass the drug test. In addition, the German firm Jenapharm, who had been supplying the government with steroids for their athletes, developed an epitestosterone product to administer to athletes to bring the ratio back to normal without discontinuing steroid use.

Their doping methods were so advanced, however, that they remained undetected for many years, until late 1989 when information was leaked to the western media about a government sponsored program of systematic anabolic steroid administration and concealment. Eventually, in the early 1990´s, the Germans had finally gotten caught, and the ensuing scandal was one which helped give anabolic steroids the bad reputation they have had ever since. Ironically, it was also in the early 1990´s that anabolic steroids had started to be used by the medical community to improve survival rates of AIDS and Cancer patients, when it was discovered that loss of lean body mass was associated with increased mortality rates respective to those diseases.

A similar story was being played out in the United States at about that same time. Before 1988, steroids were only prescription drugs, as classified by by the FDA (Food and Drug Administration). FDA determines which drugs will be classified as over-the-counter versus those which will only be available through prescription. At this time, the Federal Food, Drug, and Cosmetic Act, was invoked to restrict the access of steroids, making them available only by prescription. They were still not controlled substances at this time, however. Steroids remained in the media, occasionally making an appearance when an athlete tested positive, or admitted using them, but for another decade, they remained uncharacteristically out of the medias attention.

In the early part of the new millennium, steroids have again been pushed to the forefront of the news by the introduction of prohormones which were first developed and marketed by Patrick Arnold. It is at this point that the history of steroids in baseball begins to become more prominent; this is in all probability because Major League Baseball had no steroid testing program in effect during this time. During his epic quest to break Roger Maris home-run record, Mark Maguire was spotted by a reporter to have had a bottle of Androstendione in his locker. Although androstendione is not a steroid, and is simply a prohormone, the word steroid was again found circulating in the news on a nightly basis.

Not shortly after Roger Maris record was broken, another baseball player, Jason Giambi and various other athletes were either suspected of, or proven to have, taken anabolic steroids. Again, Congress convened a hearing, and just as they did the first time in 1990, they did not determine that steroids were a danger, but rather that the danger was more in protecting professional sports organizations. The updated statute has been updated to proscribe pro-hormones also The definition of an anabolic steroid as defined currently in the United States under is that "anabolic steroid" means any drug or hormonal substance, chemically and pharmacological related to testosterone (other than estrogens, progestins, corticosteroids, and dehydroepiandrosterone.

Currently, steroid use is far from declining. Among 12th graders surveyed in 2000, 2.5% reported using steroids at least once in their lives, while in 2004 the number was 3.4%. A recent internet study also concluded that anabolic steroid use among weightlifters and bodybuilders continues and by all accounts, there are no signs of it stopping in athletics any time soon.

In addition, the legitimate use of anabolic steroids for a variety of medical problems also continues, ranging from the treatment of Andropause or Menopause and ranging from speeding the recovery in burn victims to helping improve quality of life in Aids patients, to helping fight breast cancer and stave off osteoporosis.

Thus, the history of anabolic steroids is not something that has already occurred and been written, but rather it is a continuing history being written every day by scientists, lawmakers, doctors and of course, athletes.

1 comment:

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